N-Nitrosamines have raised extensive concern due to their high toxicity and detection in treated wastewater and drinking water. Catalytic reduction is a promising alternative technology to treat N-nitrosamines, but to advance this technology pathway, there is a need to develop more-efficient and cost-effective catalysts. We have previously discovered that commercial catalysts containing ruthenium (Ru) are unexpectedly active in reducing nitrate. This study evaluated supported Ru activity for catalyzing reduction of N-nitrosamines. Experiments with N-nitrosodimethylamine (NDMA) show that contaminant is rapidly reduced on both commercial and in-house prepared Ru/Al2O3 catalysts, with the commercial material yielding an initial metal weight-normalized pseudo-first-order rate constant ( k0) of 1103 ± 133 L·gRu-1·h-1 and an initial turnover frequency (TOF0) of 58.0 ± 7.0 h-1. NDMA is reduced to dimethylamine (DMA) and ammonia end-products, and a small amount of 1,1-dimethylhydrazine (UDMH) was detected as a transient intermediate. Experiment with a mixture of five N-nitrosamines spiked into tap water (1 μg L-1 each) demonstrates that Ru catalysts are very effective in reducing a range of N-nitrosamine structures at environmentally relevant concentrations. Cost competitiveness and high catalytic activities with a range of contaminants provide a strong argument for developing Ru catalysts as part of the water purification and remediation toolbox.