Branched-chain amino acid (BCAA) supplementation enhances adaptability to exercise training of mice with a muscle-specific defect in the control of BCAA catabolism

Minjun Xu; Yasuyuki Kitaura; Daichi Shindo; Yoshiharu Shimomura

doi:10.1080/09168451.2018.1440174

Branched-chain amino acid (BCAA) supplementation enhances adaptability to exercise training of mice with a muscle-specific defect in the control of BCAA catabolism

Biosci Biotechnol Biochem. 2018 Mar 1:1-4. doi: 10.1080/09168451.2018.1440174. Online ahead of print.

Authors

Minjun Xu¹, Yasuyuki Kitaura¹, Daichi Shindo¹, Yoshiharu Shimomura¹

Affiliation

¹ a Laboratory of Nutritional Biochemistry, Graduate School of Bioagricultural Sciences , Nagoya University , Nagoya , Japan.

PMID: 29490580
DOI: 10.1080/09168451.2018.1440174

Abstract

Branched-chain α-keto acid dehydrogenase (BCKDH) kinase (BDK) suppresses the branched-chain amino acid (BCAA) catabolism by inactivation of the BCKDH complex. The muscle-specific BDK-deficient (BDK-mKO) mice showed accelerated BCAA oxidation in muscle and decreased endurance capacity after training (Xu et al. PLoS One. 12 (2017) e0180989). We here report that BCAA supplementation overcompensated endurance capacity in BDK-mKO mice after training.

Keywords: BCAA; endurance performance; glycogen; supplement; training.