MHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immune blind spots create specific oncogenic mutation predispositions within patients and influence their prevalence across populations.
Keywords: antigen presentation; cancer; cancer predisposition; cancer susceptibility prediction; human leukocyte antigen; immunology, immunoediting; immunotherapy; major histocompatibility complex; neoantigens.