Abstract
Isolated mitochondria have been incubated in the presence of 6 micrograms/ml hematoporphyrin derivative (Photofrin II), and irradiated at lambda = 365 nm. After 2 min irradiation (30 W/m2), a congruent to 50% inhibition of citric cycle intermediates transport is observed with a rather similar photosensitivity for the succinate, citrate or oxaloacetate carriers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anions / metabolism*
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Biological Transport / drug effects
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Carboxylic Acids / metabolism
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Dihematoporphyrin Ether
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Hematoporphyrins / pharmacology*
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In Vitro Techniques
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Intracellular Membranes / drug effects
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Intracellular Membranes / metabolism
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Mitochondria, Liver / drug effects*
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Mitochondrial Swelling / drug effects
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Permeability
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Rats
Substances
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Anions
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Carboxylic Acids
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Hematoporphyrins
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Dihematoporphyrin Ether