Hematoporphyrin derivative (Photofrin II) photosensitization of isolated mitochondria: impairment of anion translocation

Biochem Biophys Res Commun. 1986 Dec 15;141(2):584-90. doi: 10.1016/s0006-291x(86)80213-3.

Abstract

Isolated mitochondria have been incubated in the presence of 6 micrograms/ml hematoporphyrin derivative (Photofrin II), and irradiated at lambda = 365 nm. After 2 min irradiation (30 W/m2), a congruent to 50% inhibition of citric cycle intermediates transport is observed with a rather similar photosensitivity for the succinate, citrate or oxaloacetate carriers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anions / metabolism*
  • Biological Transport / drug effects
  • Carboxylic Acids / metabolism
  • Dihematoporphyrin Ether
  • Hematoporphyrins / pharmacology*
  • In Vitro Techniques
  • Intracellular Membranes / drug effects
  • Intracellular Membranes / metabolism
  • Mitochondria, Liver / drug effects*
  • Mitochondrial Swelling / drug effects
  • Permeability
  • Rats

Substances

  • Anions
  • Carboxylic Acids
  • Hematoporphyrins
  • Dihematoporphyrin Ether