Ductal carcinoma in-situ arising within benign phyllodes tumours

Ann R Coll Surg Engl. 2018 Apr;100(4):e97-e102. doi: 10.1308/rcsann.2018.0024. Epub 2018 Feb 27.

Abstract

Ductal carcinoma in situ arising within a benign phyllodes tumour is a rare neoplasm of the breast. We present a case of a 19-year-old woman who had a right breast lump for six months with the above diagnosis together with a mini-review of the literature. Ultrasound revealed a 5-cm breast lump and core biopsy revealed ductal carcinoma in situ. She underwent wide local excision of the breast lump with clear margins. Final histology confirmed ductal carcinoma in situ within a fibroepithelial lesion consistent with a benign phyllodes tumour. To our knowledge, this is the youngest case of ductal carcinoma in situ arising in a phyllodes tumour to have been reported so far.

Keywords: Breast cancer; Carcinoma in situ; DCIS; Fibroepithelial tumours; Phyllodes tumour.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antineoplastic Agents, Hormonal / therapeutic use*
  • BRCA1 Protein / genetics
  • BRCA2 Protein / genetics
  • Biopsy, Large-Core Needle / methods
  • Breast / pathology
  • Breast / surgery
  • Breast Neoplasms / diagnostic imaging
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy*
  • Carcinoma, Intraductal, Noninfiltrating / diagnostic imaging
  • Carcinoma, Intraductal, Noninfiltrating / genetics
  • Carcinoma, Intraductal, Noninfiltrating / pathology
  • Carcinoma, Intraductal, Noninfiltrating / therapy*
  • Chemotherapy, Adjuvant
  • Female
  • Humans
  • Mastectomy, Segmental
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasms, Multiple Primary / diagnostic imaging
  • Neoplasms, Multiple Primary / pathology
  • Neoplasms, Multiple Primary / therapy*
  • PTEN Phosphohydrolase / genetics
  • Phyllodes Tumor / diagnostic imaging
  • Phyllodes Tumor / pathology
  • Phyllodes Tumor / therapy*
  • Sentinel Lymph Node Biopsy / methods
  • Tamoxifen / therapeutic use
  • Ultrasonography, Interventional
  • Ultrasonography, Mammary
  • Young Adult

Substances

  • Antineoplastic Agents, Hormonal
  • BRCA1 Protein
  • BRCA1 protein, human
  • BRCA2 Protein
  • BRCA2 protein, human
  • Tamoxifen
  • PTEN Phosphohydrolase
  • PTEN protein, human