Acute Respiratory Distress Syndrome: Bench-to-Bedside Approaches to Improve Drug Development

Musaddique Hussain; Chengyun Xu; Mashaal Ahmad; Abdul Majeed; Meiping Lu; Xiling Wu; Lanfang Tang; Ximei Wu

doi:10.1002/cpt.1034

Acute Respiratory Distress Syndrome: Bench-to-Bedside Approaches to Improve Drug Development

Clin Pharmacol Ther. 2018 Sep;104(3):484-494. doi: 10.1002/cpt.1034. Epub 2018 Feb 27.

Authors

Musaddique Hussain^{1

2}, Chengyun Xu^{1

2}, Mashaal Ahmad^{1

2}, Abdul Majeed³, Meiping Lu⁴, Xiling Wu⁴, Lanfang Tang⁴, Ximei Wu^{1

2}

Affiliations

¹ Department of Pharmacology, Hangzhou City, 310058, China.
² The Key Respiratory Drug Research Laboratory of China Food and Drug Administration, School of Medicine, Zhejiang University, Hangzhou City, 310058, China.
³ Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
⁴ Department of Respiratory Medicine, the Affiliated Children Hospital, School of Medicine, Zhejiang University, Hangzhou City, 310006, China.

Abstract

Despite 50 years of extensive research, no definite drug is currently available to treat acute respiratory distress syndrome (ARDS), and the supportive therapies remain the mainstay of treatment. To improve drug development for ARDS, researchers need to deeply analyze the "omics" approaches, reevaluate the suitable therapeutic targets, resolve the problems of inadequate animal modeling, develop the strategies to reduce the heterogeneity, and reconsider new therapeutic and analytical approaches for better designs of clinical trials.

Publication types

Historical Article
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Consumer Product Safety
Drug Development / history
Drug Development / methods*
Drug Discovery / history
Drug Discovery / methods*
Genetic Predisposition to Disease
Genomics
History, 20th Century
History, 21st Century
Humans
Precision Medicine
Respiratory Distress Syndrome / diagnosis
Respiratory Distress Syndrome / drug therapy*
Respiratory Distress Syndrome / genetics
Respiratory Distress Syndrome / physiopathology
Respiratory System Agents / adverse effects
Respiratory System Agents / history
Respiratory System Agents / therapeutic use*
Risk Assessment
Translational Research, Biomedical / history
Translational Research, Biomedical / methods*

Substances

Respiratory System Agents