Characterization of the Complete Nucleotide Sequences of IMP-4-Encoding Plasmids, Belonging to Diverse Inc Families, Recovered from Enterobacteriaceae Isolates of Wildlife Origin

Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02434-17. doi: 10.1128/AAC.02434-17. Print 2018 May.

Abstract

The complete nucleotide sequences of six IMP-4-encoding plasmids recovered from Enterobacteriaceae isolates of wildlife origin were characterized. Sequencing data showed that plasmids of different incompatibility groups (IncM, IncI1, IncF, and nontypeable [including an IncX5_2 and two pPrY2001-like]) carried the blaIMP-4-carrying integrons In809 or In1460. Most of the plasmids carried an mph(A) region, and chrA-like, aac(3)-IId, and blaTEM-1b genes. Finally, plasmid analysis revealed the involvement of two different IS26- and Tn1696-associated mechanisms in the mobilization of IMP-4-encoding integrons.

Keywords: Enterobacter aerogenes; Escherichia coli; In1460; In809; IncF; IncI1; IncM; IncX5_2; Proteus mirabilis; Proteus penneri.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Enterobacteriaceae / genetics*
  • Enterobacteriaceae / pathogenicity
  • Enterobacteriaceae Infections / microbiology
  • Gene Transfer, Horizontal / genetics
  • Plasmids / genetics*

Substances

  • Anti-Bacterial Agents