Regulation of epithelial to mesenchymal transition by BRCA1 in breast cancer

Satheesh Kumar Sengodan; Sreelatha K H; Revathy Nadhan; Priya Srinivas

doi:10.1016/j.critrevonc.2018.01.008

Regulation of epithelial to mesenchymal transition by BRCA1 in breast cancer

Crit Rev Oncol Hematol. 2018 Mar:123:74-82. doi: 10.1016/j.critrevonc.2018.01.008. Epub 2018 Feb 2.

Authors

Satheesh Kumar Sengodan¹, Sreelatha K H¹, Revathy Nadhan¹, Priya Srinivas²

Affiliations

¹ Cancer Research Program 5, Rajiv Gandhi Centre for Biotechnology, Thycaud P O, Poojappura, Thiruvananthapuram 695 014, Kerala, India.
² Cancer Research Program 5, Rajiv Gandhi Centre for Biotechnology, Thycaud P O, Poojappura, Thiruvananthapuram 695 014, Kerala, India. Electronic address: priyasrinivas@rgcb.res.in.

PMID: 29482782
DOI: 10.1016/j.critrevonc.2018.01.008

Abstract

Reports till its discovery has proven multiple facets of Breast Cancer type 1 susceptibility gene (BRCA1) from nucleus to cytoplasm; from DNA repair to drug resistance; from Homologous Recombination (HR) to Ubiquitination; from breast to brain; from cancer to HIV and many of the roles are still unexplored. One of the recent attractions of BRCA1 is its role in regulating breast cancer metastasis though the exact mechanism is poorly understood. In this review, we will discuss the molecular interactions between BRCA1 and the key molecules of Epithelial to Mesenchymal Transition (EMT) associated with metastasis, its associated drug resistance and the possible treatment strategy for BRCA1 mutated breast cancer.

Keywords: BRCA1; Breast cancer; Drug resistance; Metastasis; epithelial to mesenchymal transition.

Publication types

Review

MeSH terms

BRCA1 Protein / genetics
BRCA1 Protein / physiology*
Breast Neoplasms / genetics*
Breast Neoplasms / pathology
DNA Repair / genetics
Drug Resistance, Neoplasm / genetics
Epithelial-Mesenchymal Transition / genetics*
Female
Homologous Recombination / genetics
Humans
Neoplasm Metastasis

Substances

BRCA1 Protein
BRCA1 protein, human