Angiogenic potential of YKL-40 in the dynamics of tumor niche

Biomed Pharmacother. 2018 Apr:100:478-485. doi: 10.1016/j.biopha.2018.02.050. Epub 2018 Feb 23.

Abstract

A multitude of clinical studies showed the elevation of YKL-40 in subjects with different kinds of tumors. It is predicted that an inherent correlation exists between survivals of cancer patients with total YKL-40 serum levels, making this factor as a potential novel biomarker. However, the crucial role of YKL-40 in the dynamics of cancers, especially angiogenesis, has not yet been completely addressed. In this review, we highlighted the various facets of YKL-40 and its importance in cancer biology as a bio-shuttle in gene therapy.

Keywords: Angiogenesis; Cancer biology; Keyword; YKL-40 factor.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / biosynthesis*
  • Biomarkers, Tumor / blood
  • Biomarkers, Tumor / genetics
  • Chitinase-3-Like Protein 1 / biosynthesis*
  • Chitinase-3-Like Protein 1 / blood
  • Chitinase-3-Like Protein 1 / genetics
  • Genetic Therapy / trends
  • Growth Substances / biosynthesis*
  • Growth Substances / blood
  • Growth Substances / genetics
  • Humans
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Neoplasms / therapy
  • Neovascularization, Pathologic / genetics
  • Neovascularization, Pathologic / metabolism*
  • Neovascularization, Pathologic / therapy

Substances

  • Biomarkers, Tumor
  • CHI3L1 protein, human
  • Chitinase-3-Like Protein 1
  • Growth Substances