Fully automatic cervical vertebrae segmentation framework for X-ray images

Comput Methods Programs Biomed. 2018 Apr:157:95-111. doi: 10.1016/j.cmpb.2018.01.006. Epub 2018 Jan 12.

Abstract

The cervical spine is a highly flexible anatomy and therefore vulnerable to injuries. Unfortunately, a large number of injuries in lateral cervical X-ray images remain undiagnosed due to human errors. Computer-aided injury detection has the potential to reduce the risk of misdiagnosis. Towards building an automatic injury detection system, in this paper, we propose a deep learning-based fully automatic framework for segmentation of cervical vertebrae in X-ray images. The framework first localizes the spinal region in the image using a deep fully convolutional neural network. Then vertebra centers are localized using a novel deep probabilistic spatial regression network. Finally, a novel shape-aware deep segmentation network is used to segment the vertebrae in the image. The framework can take an X-ray image and produce a vertebrae segmentation result without any manual intervention. Each block of the fully automatic framework has been trained on a set of 124 X-ray images and tested on another 172 images, all collected from real-life hospital emergency rooms. A Dice similarity coefficient of 0.84 and a shape error of 1.69 mm have been achieved.

Keywords: Cervical vertebrae; Deep learning; FCN; Localization; Segmentation; UNet; X-ray.

MeSH terms

  • Algorithms
  • Automation
  • Cervical Vertebrae / diagnostic imaging*
  • Diagnostic Errors
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Neural Networks, Computer*
  • Probability
  • Radiography / methods*