Shining a Light on Black Holes in Keratinocytes

J Invest Dermatol. 2018 Mar;138(3):486-489. doi: 10.1016/j.jid.2017.11.002.

Abstract

The mechanisms by which melanins are transferred from melanocytes and stored within keratinocytes to generate skin pigmentation are hotly debated. Correia et al. and Hurbain et al. provide evidence that melanin cores of melanosomes are secreted from melanocytes and taken up and stored within non-degradative membranous organelles in keratinocytes in the basal epidermis of human skin.

Publication types

  • Comment

MeSH terms

  • Epidermal Cells
  • Humans
  • Keratinocytes
  • Melanins*
  • Melanocytes
  • Melanosomes
  • Skin Pigmentation

Substances

  • Melanins