Expression of miR-208b and miR-499 in Greek Patients with Acute Myocardial Infarction

Abstract

Background/aim: Certain microRNAs (miRs) present in human plasma are candidate biomarkers for cardiovascular diseases, including acute myocardial infarction (AMI). We examined the expression of two cardiac-specific miRs (miR-208b and miR-499) in a Greek pathological population.

Materials and methods: Plasma samples from AMI patients and healthy subjects (controls) were analyzed using TaqMan® MicroRNA assays.

Results: The concentration of both miRs was significantly elevated in AMI patients compared to healthy controls. Moreover, receiver-operating characteristic (ROC) curve analysis showed that miR-208b and miR-499 displayed similar properties with the established AMI biomarker cardiac troponin T (cTnT).

Conclusion: We showed, for the first time, that these miRs could be used as AMI biomarkers in our population as well. Our data are in agreement with those of studies based on different population groups and further strengthen the observation that plasma levels of circulating miR-208b and miR-499 could serve as potential AMI biomarkers.

Keywords: Acute myocardial infarction; Greek population; biomarkers; microRNAs; plasma.