Total kidney volume: the most valuable predictor of autosomal dominant polycystic kidney disease progression

Cheng Xue; Chenchen Zhou; Changlin Mei

doi:10.1016/j.kint.2017.10.027

Total kidney volume: the most valuable predictor of autosomal dominant polycystic kidney disease progression

Kidney Int. 2018 Mar;93(3):540-542. doi: 10.1016/j.kint.2017.10.027.

Authors

Cheng Xue¹, Chenchen Zhou¹, Changlin Mei²

Affiliations

¹ Kidney Institute, Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
² Kidney Institute, Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address: chlmei1954@126.com.

PMID: 29475545
DOI: 10.1016/j.kint.2017.10.027

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive development of kidney cysts resulting in damage to kidney structure and function. Yu et al. showed that height-adjusted total kidney volume (htTKV) was a significant independent predictor of ADPKD progression after a follow-up of 14.5 years. The genotype was not an independent prognostic factor after adjusting for htTKV. This commentary discusses several considerations in model comparison, biomarker validation, and future challenges in ADPKD research.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Biomarkers
Disease Progression
Humans
Kidney*
Organ Size
Polycystic Kidney, Autosomal Dominant*

Substances

Biomarkers