Zwitterionic cocrystal of diclofenac and l-proline: Structure determination, solubility, kinetics of cocrystallization, and stability study

Eur J Pharm Sci. 2018 May 30:117:168-176. doi: 10.1016/j.ejps.2018.02.020. Epub 2018 Feb 21.

¹ School of Pharmacy, Bandung Institute of Technology, Bandung, Jawa Barat 40132, Indonesia. Electronic address: ilma_nugrahani@fa.itb.ac.id.
² School of Pharmacy, Bandung Institute of Technology, Bandung, Jawa Barat 40132, Indonesia; Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta 55166, Indonesia.
³ School of Pharmacy, Bandung Institute of Technology, Bandung, Jawa Barat 40132, Indonesia.
⁴ Department of Chemistry, School of Science, Tokyo Institute of Technology, Tokyo 152-8550, Japan.

No abstract available

Keywords: Co-grinding; Cocrystal; Diclofenac; Solubility; Stability; l-Proline.

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