Ibrutinib-Induced Neutrophilic Dermatosis

Am J Dermatopathol. 2018 Mar;40(3):198-200. doi: 10.1097/DAD.0000000000000862.

Abstract

We report the case of a 64-year-old woman treated with ibrutinib for a chronic lymphocytic leukemia with 17p deletion, who developed several erythematous, painful, and papulo-nodular skin lesions in the limbs, neck, and face. The skin biopsy was consistent with the diagnosis of neutrophilic dermatosis. Rechallenge with ibrutinib at full dose was followed by the recurrence of the same skin lesions, strongly suggesting a direct relationship.

Publication types

  • Case Reports

MeSH terms

  • Adenine / analogs & derivatives
  • Antineoplastic Agents / adverse effects*
  • Chromosomes, Human, Pair 17
  • Drug Eruptions / etiology*
  • Drug Eruptions / pathology*
  • Female
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
  • Middle Aged
  • Piperidines
  • Pyrazoles / adverse effects*
  • Pyrimidines / adverse effects*
  • Sweet Syndrome / chemically induced
  • Sweet Syndrome / pathology

Substances

  • Antineoplastic Agents
  • Piperidines
  • Pyrazoles
  • Pyrimidines
  • ibrutinib
  • Adenine