Outcomes after surgical coronary artery revascularisation in children with congenital heart disease

Heart. 2018 Sep;104(17):1417-1423. doi: 10.1136/heartjnl-2017-312652. Epub 2018 Feb 22.

Abstract

Objective: Surgical coronary revascularisation in children with congenital heart disease (CHD) is a rare event for which limited information is available. In this study, we review the indications and outcomes of surgical coronary revascularisation from the Pediatric Cardiac Care Consortium, a large US-based multicentre registry of interventions for CHD.

Methods: This is a retrospective cohort study of children (<18 years old) with CHD who underwent surgical coronary revascularisation between 1982 and 2011. In-hospital mortality and graft patency data were obtained from the registry. Long-term transplant-free survival through 2014 was achieved for patients with adequate identifiers via linkage with the US National Death Index and the Organ Procurement and Transplantation Network.

Results: Coronary revascularisation was accomplished by bypass grafting (n=72, median age 6.8 years, range 3 days-17.4 years) or other operations (n=65, median age 2.6 years, range 5 days-16.7 years) in 137 patients. Most revascularisations were related to the aortic root (61.3%) or coronary anomalies (27.7%), but 10.9% of them were unrelated to either of them. Twenty in-hospital deaths occurred, 70% of them after urgent 'rescue' revascularisation in association with another operation. Long-term outcomes were available by external linkage for 54 patients surviving to hospital discharge (median follow-up time 15.0 years, max follow-up 29.8 years) with a 15-year transplant-free survival of 91% (95% CI 83% to 99%).

Conclusions: Surgical coronary revascularisation can be performed in children with CHD with acceptable immediate and long-term survival. Outcomes are dependent on indication, with the highest mortality in rescue procedures.

Keywords: congenital heart disease; congenital heart disease surgery.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Heart Defects, Congenital / epidemiology
  • Heart Defects, Congenital / surgery*
  • Hospital Mortality
  • Humans
  • Infant, Newborn
  • Long Term Adverse Effects* / epidemiology
  • Long Term Adverse Effects* / etiology
  • Male
  • Myocardial Revascularization* / adverse effects
  • Myocardial Revascularization* / classification
  • Myocardial Revascularization* / methods
  • Myocardial Revascularization* / mortality
  • Outcome and Process Assessment, Health Care
  • Registries / statistics & numerical data
  • Retrospective Studies
  • Survival Analysis
  • United States / epidemiology