Cytotoxic alkaloids from Pogonopus tubulosus: G2/M cell cycle arrest and inhibition of DNA topoisomerase IIα by isotubulosine

Phytother Res. 2018 May;32(5):943-948. doi: 10.1002/ptr.6059. Epub 2018 Feb 22.
No abstract available

Keywords: Pogonopus tubulosus; Rubiaceae; alangiside; isotubulosine; topoisomerase.

MeSH terms

  • Alkaloids
  • DNA Topoisomerases, Type II / metabolism*
  • G2 Phase Cell Cycle Checkpoints / genetics*
  • Humans
  • Rubiaceae / chemistry*

Substances

  • Alkaloids
  • DNA Topoisomerases, Type II