Cough and ACE Inhibitors: The Truth Beyond Placebo

Clin Pharmacol Ther. 2019 Mar;105(3):550-552. doi: 10.1002/cpt.1040. Epub 2018 Feb 22.

Abstract

Angiotensin converting enzyme (ACE) inhibitors are extensively used for the prevention and treatment of cardiovascular diseases with a wide range of clinical recommendations. The use of ACE inhibitors can cause the onset of a dry cough, whose prevalence has probably been overestimated because of the lack of adequate control. A correct interpretation of available data requires a careful evaluation of placebo-controlled studies to definitely assess the rate of the most frequent adverse event of ACE inhibition.

Publication types

  • Comment

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors*
  • Cardiovascular Diseases*
  • Cough
  • Humans
  • Prevalence

Substances

  • Angiotensin-Converting Enzyme Inhibitors