Membrane detachment is not essential for COG complex function

Mol Biol Cell. 2018 Apr 15;29(8):964-974. doi: 10.1091/mbc.E17-11-0694. Epub 2018 Mar 30.

Abstract

COG is a multisubunit vesicle tethering complex in the Golgi. We demonstrate that both COG subcomplexes can be permanently attached to Golgi membranes and that major COG functions do not require cycling between the membrane and cytosol.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adaptor Proteins, Vesicular Transport / metabolism*
  • Glycosylation
  • Golgi Apparatus / physiology*
  • HEK293 Cells
  • Humans
  • Membrane Proteins / metabolism*
  • Protein Subunits / metabolism
  • Protein Transport
  • Vesicular Transport Proteins / metabolism*

Substances

  • Adaptor Proteins, Vesicular Transport
  • COG4 protein, human
  • COG7 protein, human
  • COG8 protein, human
  • Membrane Proteins
  • Protein Subunits
  • TMEM115 protein, human
  • Vesicular Transport Proteins