Liver involvement in dengue viral infections

Rev Med Virol. 2018 Mar;28(2). doi: 10.1002/rmv.1971. Epub 2018 Feb 21.

Abstract

Dengue fever is the commonest viral haemorrhagic fever worldwide and is a leading cause of morbidity and mortality in the tropics. Dengue viral infections are frequently associated with varying degrees of liver injury. Liver injury is more severe in dengue haemorrhagic fever or severe dengue. We review the current knowledge on liver involvement following dengue viral infections and explore the links between clinical manifestations, pathogenesis, and their impact on management.

Keywords: animal; dengue; human; liver; pathogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Dengue / complications*
  • Dengue / diagnosis
  • Dengue / epidemiology
  • Dengue / virology*
  • Dengue Virus / classification
  • Dengue Virus / physiology*
  • Disease Management
  • Humans
  • Liver Diseases / diagnosis
  • Liver Diseases / epidemiology
  • Liver Diseases / etiology*
  • Liver Diseases / therapy
  • Liver Function Tests