We detected Cache Valley virus in Aedes japonicus, a widely distributed invasive mosquito species, in an Appalachian forest in the United States. The forest contained abundant white-tailed deer, a major host of the mosquito and virus. Vector competence trials indicated that Ae. j. japonicus mosquitoes can transmit this virus in this region.
Keywords: Aedes japonicus japonicus; Appalachian Region; Blacksburg; Cache Valley virus; United States; Virginia; mosquitoes; vector competence; vector-borne infections; viruses; zoonoses.