Pharmacogenetic study of pruritus induced by epidural morphine for post cesarean section analgesia

Chia-Chi Kung; Shiou-Sheng Chen; Hong-Jyh Yang; Chih-Jun Lai; Li-Kuei Chen

doi:10.1016/j.tjog.2017.12.015

Pharmacogenetic study of pruritus induced by epidural morphine for post cesarean section analgesia

Taiwan J Obstet Gynecol. 2018 Feb;57(1):89-94. doi: 10.1016/j.tjog.2017.12.015.

Authors

Chia-Chi Kung¹, Shiou-Sheng Chen², Hong-Jyh Yang³, Chih-Jun Lai¹, Li-Kuei Chen⁴

Affiliations

¹ Department of Anesthesiology, National Taiwan University Hospital Hsin- Chu Branch, Hsinchu City, 30059, Taiwan.
² Department of Urology, School of Medicine, National Yang-Ming University, Taipei, 112, Taiwan; Division of Urology, Taipei City Hospital Heping Fuyou Branch, 100, Taipei, Taiwan.
³ Department of Internal Medicine, National Taiwan University Hospital Hsin- Chu Branch, Hsinchu City, 30059, Taiwan.
⁴ Department of Anesthesiology, National Taiwan University Hospital Hsin- Chu Branch, Hsinchu City, 30059, Taiwan; Department of Anesthesiology, National Taiwan University Hospital, 100, Taiwan; Department of Anesthesiology, School of Medicine, National Taiwan University, 100, Taiwan; Department of Anesthesiology, School of Medicine, Chung Shan Medical University, Taiwan. Electronic address: clk0619@ntu.edu.tw.

PMID: 29458911
DOI: 10.1016/j.tjog.2017.12.015

Abstract

Objective: The mechanism through which neuroaxial morphine causes pruritus has not been elucidated clearly and thoroughly.

Materials and methods: a study in 129 female parturients was conducted to investigate the effect of 14 single nucleotide polymorphisms (SNPs) on phenotype (pruritus) induced by neuroaxial (including intrathecal or epidural) morphine for cesarean section. Clinical phenotype, subjective complaints and objective observations were recorded. DNA from blood samples was used to record the SNPs. Eleven SNPs were then analyzed further.

Results: no significant association with the presence of phenotype (pruritus) versus genotype was observed (all p-values > 0.05). No significant association with severity of phenotype versus genotype of the 11 SNPs was observed except for unadjusted data for rs2737703. There was no significant difference between severity or incidence of IVPCA morphine-induced nausea and vomiting and genotype (11 SNPs).

Conclusion: our results showed no association between SNPs of any of the genes studied with neuroaxial morphine inducing pruritus.

Keywords: Morphine; Neuroaxial; Phenotype; Pruritis; Single nucleotide polymorphisms (SNPs).

Publication types

Observational Study

MeSH terms

Analgesia, Epidural / adverse effects
Analgesics, Opioid / administration & dosage
Analgesics, Opioid / adverse effects*
Cesarean Section / adverse effects
Female
Genotype
Humans
Morphine / administration & dosage
Morphine / adverse effects*
Pain Management
Pain, Postoperative / drug therapy*
Pharmacogenomic Testing / methods
Phenotype
Polymorphism, Single Nucleotide
Pregnancy
Prospective Studies
Pruritus / chemically induced
Pruritus / genetics*
Taiwan

Substances

Analgesics, Opioid
Morphine