Structural fingerprints, interactions, and signaling networks of RAS family proteins beyond RAS isoforms

Crit Rev Biochem Mol Biol. 2018 Apr;53(2):130-156. doi: 10.1080/10409238.2018.1431605. Epub 2018 Feb 19.

Authors

Saeideh Nakhaei-Rad¹, Fereshteh Haghighi¹, Parivash Nouri¹, Soheila Rezaei Adariani¹, Jana Lissy¹, Neda S Kazemein Jasemi¹, Radovan Dvorsky¹, Mohammad Reza Ahmadian¹

Affiliation

¹ a Institute of Biochemistry and Molecular Biology II, Medical Faculty , Heinrich-Heine University , Düsseldorf , Germany.

PMID: 29457927
DOI: 10.1080/10409238.2018.1431605

No abstract available

Keywords: Effectors; GAPs; GEFs; RAS; protein family; scaffold proteins; signal transduction.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cardiovascular Diseases / genetics
Cardiovascular Diseases / metabolism
Cardiovascular Diseases / pathology
GTP Phosphohydrolases / chemistry
GTP Phosphohydrolases / genetics
GTP Phosphohydrolases / metabolism*
Humans
Isoenzymes / chemistry
Isoenzymes / genetics
Isoenzymes / metabolism
Membrane Proteins / chemistry
Membrane Proteins / genetics
Membrane Proteins / metabolism*
Metabolic Diseases / genetics
Metabolic Diseases / metabolism
Metabolic Diseases / pathology
Neoplasms / genetics
Neoplasms / metabolism
Neoplasms / pathology
Proto-Oncogene Proteins p21(ras) / chemistry
Proto-Oncogene Proteins p21(ras) / genetics
Proto-Oncogene Proteins p21(ras) / metabolism*
Signal Transduction*
Structure-Activity Relationship

Substances

Isoenzymes
KRAS protein, human
Membrane Proteins
GTP Phosphohydrolases
NRAS protein, human
HRAS protein, human
Proto-Oncogene Proteins p21(ras)