Abstract
A new alkylamide, named (2E,6E,8E)-N-(2-methylpropyl)-10-oxo-2,6,8-decatrienamide (1), together with 22 known compounds (2-23), were isolated from the stems of Zanthoxylum nitidum. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR spectroscopy. The isolated compounds exhibited slightly antioxidant activities through DPPH and ABTS radical scavenging assays but showed no antibacterial activity against Streptococcus mutans ATCC2517, a dental caries causing bacteria.
Keywords:
Rutaceae; alkylamide; antibacterial; antioxidant.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Dental Caries / microbiology
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Drug Evaluation, Preclinical
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology
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Humans
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Molecular Structure
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Plant Extracts / chemistry
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Plant Stems / chemistry
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Polyunsaturated Alkamides / chemistry
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Polyunsaturated Alkamides / isolation & purification
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Polyunsaturated Alkamides / pharmacology*
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Stereoisomerism
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Streptococcus mutans / drug effects
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Zanthoxylum / chemistry*
Substances
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Anti-Bacterial Agents
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Antioxidants
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Free Radical Scavengers
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Plant Extracts
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Polyunsaturated Alkamides