A systematic review of the literature exploring the interplay between prostate cancer and type two diabetes mellitus

Danielle Crawley; Florence Chamberlain; Hans Garmo; Sarah Rudman; Björn Zethelius; Lars Holmberg; Jan Adolfsson; Par Stattin; Paul Carroll; Mieke Van Hemelrijck

doi:10.3332/ecancer.2018.802

A systematic review of the literature exploring the interplay between prostate cancer and type two diabetes mellitus

Ecancermedicalscience. 2018 Jan 25:12:802. doi: 10.3332/ecancer.2018.802. eCollection 2018.

Authors

Danielle Crawley¹, Florence Chamberlain², Hans Garmo¹, Sarah Rudman², Björn Zethelius^{3

4}, Lars Holmberg^{1

5}, Jan Adolfsson⁶, Par Stattin⁵, Paul Carroll⁷, Mieke Van Hemelrijck¹

Affiliations

¹ Translational Oncology and Urology Research Group, King's College London, London SE1 9RT, UK.
² Department of Medical Oncology, Guy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK.
³ Department of Public Health and Geriatrics, Uppsala University, Uppsala 751 05, Sweden.
⁴ Medical Products Agency, Uppsala 751 03, Sweden.
⁵ Department of Surgical Sciences, Uppsala University, Uppsala 751 05, Sweden.
⁶ Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm 171 77, Sweden.
⁷ Department of Diabetes and Endocrinology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 9RT UK.

Abstract

Prostate cancer (PCa) and type two diabetes mellitus (T2DM) are both increasing prevalent conditions and often occur concurrently. However, the relationship between the two is more complex than just two prevalent conditions co-existing. This review systematically explores the literature around the interplay between the two conditions. It covers the impact of pre-existing T2DM on PCa incidence, grade and stage, as well as exploring the impact of T2DM on PCa outcomes and mortality and the interaction between T2DM and PCa treatments.

Keywords: prostate cancer; review; type two diabetes.

Publication types

Review