Abstract
The ability of serotonin, melatonin and beta-endorphin synthesis by secreting granules of natural killer cells (NK cells) was established by immunohistochemical method. It was shown that cytotoxic effect of NK cells can be to a certain extent related to the presence of secreting granules. A possible direct contribution of NK cell-synthesized hormones to the natural killer antitumour effect is discussed.
MeSH terms
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Animals
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Cytoplasmic Granules / metabolism*
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Cytoplasmic Granules / ultrastructure
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Endorphins / metabolism*
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Histocytochemistry
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Humans
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Immunoenzyme Techniques
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Killer Cells, Natural / metabolism*
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Killer Cells, Natural / ultrastructure
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Melatonin / metabolism*
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Microscopy, Electron
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Rats
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Rats, Inbred Strains
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Serotonin / metabolism*
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beta-Endorphin
Substances
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Endorphins
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Serotonin
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beta-Endorphin
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Melatonin