The role of the OVOL1-OVOL2 axis in normal and diseased human skin

Gaku Tsuji; Takamichi Ito; Takahito Chiba; Chikage Mitoma; Takeshi Nakahara; Hiroshi Uchi; Masutaka Furue

doi:10.1016/j.jdermsci.2018.02.005

The role of the OVOL1-OVOL2 axis in normal and diseased human skin

J Dermatol Sci. 2018 Jun;90(3):227-231. doi: 10.1016/j.jdermsci.2018.02.005. Epub 2018 Feb 12.

Authors

Gaku Tsuji¹, Takamichi Ito², Takahito Chiba², Chikage Mitoma³, Takeshi Nakahara⁴, Hiroshi Uchi², Masutaka Furue⁵

Affiliations

¹ Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan. Electronic address: gakku@dermatol.med.kyushu-u.ac.jp.
² Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan.
³ Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan; Research and Clinical Center for Yusho and Dioxin, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan.
⁴ Research and Clinical Center for Yusho and Dioxin, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan; Division of Skin Surface Sensing, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan.
⁵ Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan; Research and Clinical Center for Yusho and Dioxin, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan; Division of Skin Surface Sensing, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan.

PMID: 29454536
DOI: 10.1016/j.jdermsci.2018.02.005

Abstract

OVOLs (OVO-like proteins) are ubiquitously conserved genes encoding a C₂H₂ zinc finger transcription factor in mammals. Functional studies on OVOL1 and OVOL2 using knockout mice have suggested that these genes play a pivotal role in the development of epithelial tissues arising from germ cells; however, the role of the OVOL1-OVOL2 axis in normal and diseased tissues remains unclear. This review highlights recent advances in understanding how the OVOL1-OVOL2 axis modulates cell differentiation and proliferation in human keratinocytes, hair follicles, and benign or malignant skin tumors including squamous cell carcinoma and malignant melanoma. Furthermore, OVOL1 has been shown to be involved in the expression of skin barrier proteins including filaggrin (FLG), and its mutation or dysfunction leads to the development of atopic dermatitis (AD). OVOL1 has also been identified as a susceptibility gene for AD by genome-wide association studies, in addition to FLG. Therefore, we discuss the relationship between OVOL1 and FLG in the development of AD.

Keywords: Aryl hydrocarbon receptor (AHR); Atopic dermatitis; Cutaneous squamous cell carcinoma; OVOL1; OVOL2.

Publication types

Review

MeSH terms

Animals
Cell Differentiation / physiology
Cell Proliferation / physiology
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism*
Dermatitis, Atopic / genetics*
Dermatitis, Atopic / pathology
Filaggrin Proteins
Genetic Predisposition to Disease
Humans
Intermediate Filament Proteins / genetics
Intermediate Filament Proteins / metabolism
Keratinocytes / metabolism
Mice
Neoplasm Invasiveness / genetics
Neoplasm Invasiveness / pathology
Skin / cytology
Skin / metabolism*
Skin Neoplasms / genetics
Skin Neoplasms / pathology*
Transcription Factors / genetics
Transcription Factors / metabolism*

Substances

DNA-Binding Proteins
FLG protein, human
Filaggrin Proteins
Intermediate Filament Proteins
OVOL1 protein, human
Ovol2 protein, human
Transcription Factors