Diversion of complement-mediated killing by Bordetella

Anaïs Thiriard; Dominique Raze; Camille Locht

doi:10.1016/j.micinf.2018.02.002

Diversion of complement-mediated killing by Bordetella

Microbes Infect. 2018 Oct-Nov;20(9-10):512-520. doi: 10.1016/j.micinf.2018.02.002. Epub 2018 Feb 14.

Authors

Anaïs Thiriard¹, Dominique Raze¹, Camille Locht²

Affiliations

¹ Université de Lille, CNRS UMR 8204, Inserm U1019, CHU Lille, Institut Pasteur de Lille, Centre for Infection and Immunity of Lille, F-59000 Lille, France.
² Université de Lille, CNRS UMR 8204, Inserm U1019, CHU Lille, Institut Pasteur de Lille, Centre for Infection and Immunity of Lille, F-59000 Lille, France. Electronic address: Camille.locht@pasteur-lille.fr.

PMID: 29454132
DOI: 10.1016/j.micinf.2018.02.002

Abstract

The complement cascade participates in protection against bacterial infections, and pathogens, including Bordetella pertussis, have developed complement-evading strategies. Here we discuss current knowledge on B. pertussis complement evasion strategies and the role of antibody-dependent complement-mediated killing in protection against B. pertussis infection pointing out important knowledge gaps for further research to improve current pertussis vaccines.

Keywords: Antibodies; Bordetella; Complement; Pertussis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antibodies, Bacterial / immunology
Bacterial Proteins / immunology
Bordetella pertussis / immunology*
Complement Activation / immunology*
Complement System Proteins / immunology
Humans
Immune Evasion / immunology*
Pertussis Vaccine / immunology
Whooping Cough / immunology*

Substances

Antibodies, Bacterial
Bacterial Proteins
Pertussis Vaccine
Complement System Proteins