An unusual presentation of primary pulmonary extranodal marginal zone lymphoma of mucosal associated lymphoid tissue: An autopsy case report

Exp Mol Pathol. 2018 Apr;104(2):155-157. doi: 10.1016/j.yexmp.2018.02.003. Epub 2018 Feb 13.

Abstract

A 40 year old female with no documented medical history presented to the Emergency Department with several days of lethargy and altered mental status. She was found to be anemic, thrombocytopenic, and hypotensive. The patient was found to be in severe metabolic acidosis, became bradycardic, and quickly deteriorated. Clinicians suspected thrombotic thrombocytopenic purpura, and the diagnosis was supported by ADAMTS13 testing. The clinicians attempted to place a Quinton catheter for emergent plasmapheresis, but the patient expired before definitive treatment could be initiated. Autopsy was obtained and revealed a right middle lobe consolidation grossly consistent with lymphoid tissue or tumor.

Keywords: ADAMTS13; Autopsy; Extranodal marginal zone lymphoma; MALT lymphoma; Thrombotic thrombocytopenic purpura.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • ADAMTS13 Protein / blood
  • Adult
  • Autopsy
  • Female
  • Humans
  • Lung Neoplasms / pathology*
  • Lymphoma, B-Cell, Marginal Zone / pathology*
  • Purpura, Thrombotic Thrombocytopenic / diagnosis

Substances

  • ADAMTS13 Protein
  • ADAMTS13 protein, human