Microstructurally Anchored Cardiac Kinematics by Combining In Vivo DENSE MRI and cDTI

Luigi E Perotti; Patrick Magrath; Ilya A Verzhbinsky; Eric Aliotta; Kévin Moulin; Daniel B Ennis

doi:10.1007/978-3-319-59448-4_36

Microstructurally Anchored Cardiac Kinematics by Combining In Vivo DENSE MRI and cDTI

Funct Imaging Model Heart. 2017 Jun:10263:381-391. doi: 10.1007/978-3-319-59448-4_36. Epub 2017 May 23.

Authors

Luigi E Perotti^{1

2}, Patrick Magrath^{1

2}, Ilya A Verzhbinsky¹, Eric Aliotta^{1

3}, Kévin Moulin¹, Daniel B Ennis^{1

2

3}

Affiliations

¹ Department of Radiological Sciences, University of California, Los Angeles, USA.
² Department of Bioengineering, University of California, Los Angeles, USA.
³ Department of Biomedical Physics IDP, University of California, Los Angeles, USA.

Abstract

Metrics of regional myocardial function can detect the onset of cardiovascular disease, evaluate the response to therapy, and provide mechanistic insight into cardiac dysfunction. Knowledge of local myocardial microstructure is necessary to distinguish between isotropic and anisotropic contributions of local deformation and to quantify myofiber kinematics, a microstructurally anchored measure of cardiac function. Using a computational model we combine in vivo cardiac displacement and diffusion tensor data to evaluate pointwise the deformation gradient tensor and isotropic and anisotropic deformation invariants. In discussing the imaging methods and the model construction, we identify potential improvements to increase measurement accuracy. We conclude by demonstrating the applicability of our method to compute myofiber strain in five healthy volunteers.

Keywords: Cardiac deformation invariants; Cardiac kinematics; Diffusion tensor imaging; Myofiber strain.

Abstract

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