Immunomodulation by food: impact on gut immunity and immune cell function

Biosci Biotechnol Biochem. 2018 Apr;82(4):584-599. doi: 10.1080/09168451.2018.1433017. Epub 2018 Feb 16.

Abstract

Recent studies have revealed that various food components affect the immune response. These components act on various immune cells, and their effects are mediated through the intestinal immune system and, in some cases, the intestinal microbiota. In this review, we describe the immunomodulating effects of various food components, including probiotics, prebiotics, polysaccharides, vitamins, minerals, fatty acids, peptides, amino acids and polyphenols. Some of these components enhance immune responses, leading to host defense against infection, whereas others inhibit immune responses, thus suppressing allergy and inflammation.

Keywords: Immunomodulation; anti-allergy; food factors; gut immunity; probiotics and prebiotics.

Publication types

  • Review

MeSH terms

  • Amino Acids / administration & dosage
  • Amino Acids / pharmacology
  • Animals
  • Bacteria / metabolism
  • Fatty Acids / administration & dosage
  • Fatty Acids / pharmacology
  • Food*
  • Gastrointestinal Microbiome
  • Humans
  • Hypersensitivity / immunology
  • Hypersensitivity / prevention & control
  • Immunity, Cellular
  • Immunomodulation*
  • Inflammation / immunology
  • Inflammation / prevention & control
  • Intestines / immunology*
  • Intestines / microbiology
  • Minerals / administration & dosage
  • Minerals / pharmacology
  • Polysaccharides / metabolism
  • Prebiotics
  • Probiotics
  • Vitamins / administration & dosage
  • Vitamins / pharmacology

Substances

  • Amino Acids
  • Fatty Acids
  • Minerals
  • Polysaccharides
  • Prebiotics
  • Vitamins