A Balancing Act: PGRPs Preserve and Protect

Roman Dziarski; Dipika Gupta

doi:10.1016/j.chom.2018.01.010

A Balancing Act: PGRPs Preserve and Protect

Cell Host Microbe. 2018 Feb 14;23(2):149-151. doi: 10.1016/j.chom.2018.01.010.

Authors

Roman Dziarski¹, Dipika Gupta²

Affiliations

¹ Indiana University School of Medicine-Northwest, Gary, IN 46408, USA. Electronic address: rdziar@iun.edu.
² Indiana University School of Medicine-Northwest, Gary, IN 46408, USA.

PMID: 29447691
DOI: 10.1016/j.chom.2018.01.010

Abstract

How does the immune system maintain a balance between preserving a beneficial microbiome and protecting against pathogens while also inducing effective, yet not damaging, responses? In this issue of Cell Host & Microbe, Charroux et al. (2018) reveal that, in Drosophila, this task is performed by three isoforms of PGRP-LB, a peptidoglycan-hydrolyzing amidase.

Publication types

Comment

MeSH terms

Animals
Carrier Proteins / immunology*
Drosophila / immunology*
Drosophila Proteins / immunology
Peptidoglycan

Substances

Carrier Proteins
Drosophila Proteins
Peptidoglycan

Grants and funding

R01 AI120962/AI/NIAID NIH HHS/United States