Metaplastic Cdx2-depleted cells can be very disruptive neighbors

Filipe C Lourenço; Douglas J Winton

doi:10.1084/jem.20180215

Metaplastic Cdx2-depleted cells can be very disruptive neighbors

J Exp Med. 2018 Mar 5;215(3):725-727. doi: 10.1084/jem.20180215. Epub 2018 Feb 12.

Authors

Filipe C Lourenço¹, Douglas J Winton²

Affiliations

¹ Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, England, UK Filipe.Lourenco@cruk.cam.ac.uk.
² Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, England, UK Doug.Winton@cruk.cam.ac.uk.

Abstract

In this issue of JEM, Balbinot et al. (https://doi.org/10.1084/jem.20170934) describe an original mechanism where Cdx2 inactivation regulates intestinal metaplastic to neoplastic transition in a paracrine fashion. Surprisingly, the target cells are neighboring "normal" Cdx2-positive cells.

Publication types

Comment

MeSH terms

Animals
CDX2 Transcription Factor
Carcinogenesis
Genes, Homeobox*
Homeodomain Proteins / genetics*
Mice
Mice, Transgenic

Substances

CDX2 Transcription Factor
Cdx2 protein, mouse
Homeodomain Proteins

Grants and funding

17044/CRUK_/Cancer Research UK/United Kingdom