Abstract
A novel approach to the production of chiral 1,3-cyclohexadienals has been developed. The organocatalysed asymmetric reaction of different β-disubstituted-α,β-unsaturated aldehydes with a chiral α,β-unsaturated aldehyde in the presence of a Jørgensen-Hayashi organocatalyst provides easy and stereocontrolled access to the cyclohexadienal backbone. This method allows for the synthesis of potential photoprotective chiral 1,3-cyclohexadienals and extra extended conjugation compounds in a simple manner.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry*
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Carbon-13 Magnetic Resonance Spectroscopy
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Crystallography, X-Ray
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Cyclohexenes / chemical synthesis*
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Cyclohexenes / chemistry
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Models, Molecular
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Proton Magnetic Resonance Spectroscopy
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Spectrometry, Mass, Electrospray Ionization
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Stereoisomerism
Substances
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Aldehydes
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Cyclohexenes
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1,3-cyclohexadiene
Grants and funding
Financial support for this work was provided by the Ministry of Economy and Competitiveness (MINECO) CTQ2015-68175-R, the European Regional Development Fund (FEDER), the Regional Government of Castile & Leon (BIO/SA59/15, UIC21) and the Universidad de Salamanca. AU thanks the Regional Government of Castile & Leon-European Social Fund (JCyL-FSE), IET thanks the Regional Government of Castile & Leon and MCC thanks the Universidad de Salamanca for their fellowships.