Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation

Affiliations

• ¹ Department of Pathology, University of California, San Francisco, 513 Parnassus Ave, Health Sciences West 451, San Francisco, CA, 94143, USA.
• ² Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
• ³ Clinical Cancer Genomics Laboratory, University of California, San Francisco, CA, USA.
• ⁴ Hopp Children's Cancer Center, NCT Heidelberg (KiTZ), Heidelberg, Germany.
• ⁵ Division of Pediatric Neuro-oncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
• ⁶ Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.
• ⁷ Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
• ⁸ Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
• ⁹ Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, Heidelberg, Germany.
• ¹⁰ Division of Pediatric Hematology/Oncology, Valley Children's Hospital, Madera, CA, USA.
• ¹¹ Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California, San Francisco, CA, USA.
• ¹² Department of Neurological Surgery, University of California, San Francisco, CA, USA.
• ¹³ Department of Neurology, University of California, San Francisco, CA, USA.
• ¹⁴ Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.
• ¹⁵ Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.
• ¹⁶ Department of Pathology, University of California, San Francisco, 513 Parnassus Ave, Health Sciences West 451, San Francisco, CA, 94143, USA. david.solomon@ucsf.edu.
• ¹⁷ Clinical Cancer Genomics Laboratory, University of California, San Francisco, CA, USA. david.solomon@ucsf.edu.