Copper(ii)-mediated, carbon degradation-based amidation of phenylacetic acids toward N-substituted benzamides

Leiling Deng; Bin Huang; Yunyun Liu

doi:10.1039/c8ob00064f

Copper(ii)-mediated, carbon degradation-based amidation of phenylacetic acids toward N-substituted benzamides

Org Biomol Chem. 2018 Feb 28;16(9):1552-1556. doi: 10.1039/c8ob00064f.

Authors

Leiling Deng¹, Bin Huang, Yunyun Liu

Affiliation

¹ College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P.R. China. chemliuyunyun@jxnu.edu.cn.

PMID: 29435543
DOI: 10.1039/c8ob00064f

Abstract

The unprecedented synthesis of N-aryl substituted benzamides via the assembly of primary amines and phenylacetic acids has been developed in the presence of copper(ii) acetate. This tandem transformation involving carbon-carbon bond cleavage provides a complementary tool with particular application in the synthesis of secondary benzamides.