Pharmaceutical opioid overdose deaths and the presence of witnesses

Int J Drug Policy. 2018 May:55:8-13. doi: 10.1016/j.drugpo.2017.12.020. Epub 2018 Feb 10.

Abstract

Background: In the past two decades, rates of pharmaceutical opioid use and harms resulting from their use (including death) have risen. The present study identified a series of fatal opioid overdoses where there was evidence that witnesses had noted symptoms consistent with overdose, and examined associated contextual factors.

Methods: A retrospective review was undertaken utilising the Coroners Court of Victoria's Overdose Deaths Register for pharmaceutical opioid overdose deaths between 2011 and 2013. Information on the source of pharmaceutical opioids, co-contributing drugs, history of drug dependence, and mental illness was extracted and coded.

Results: Pharmaceutical opioids were involved in 587 deaths, and within these, 125 cases (21%) were witnessed. The majority of these witnessed deaths (77.6%) occurred at the deceased's residence, with the witness being a partner or unrelated acquaintance who did not realise the significance of what they were witnessing. The most common contributing pharmaceutical opioids were methadone (49.6%), codeine (32.0%), and oxycodone (19.2%), with the source more often prescribed than diverted. Co-contributing drugs were involved in 110 cases, with the most common being benzodiazepines. Evidence of current dependence and mental illness was found in 53.6% of cases.

Conclusion: Most pharmaceutical opioid overdose deaths with a witness present occurred in the deceased's home, with symptoms of overdose being noted, but not acted upon. These findings support the trialling of education and/or naloxone to partners and family members of people who use pharmaceutical opioids in order to reduce overdose deaths.

Keywords: Deaths; Drug overdose; Drug toxicity; Health education; Pharmaceutical opioids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Analgesics, Opioid / adverse effects*
  • Awareness*
  • Comorbidity
  • Drug Interactions
  • Drug Overdose / epidemiology*
  • Drug Overdose / mortality*
  • Female
  • Humans
  • Male
  • Mental Disorders / epidemiology*
  • Middle Aged
  • Registries / statistics & numerical data
  • Retrospective Studies
  • Substance-Related Disorders / epidemiology*
  • Victoria / epidemiology
  • Young Adult

Substances

  • Analgesics, Opioid