Abstract
We report a case of a 12-year-old male with glucose-6-phosphate dehydrogenase deficiency presenting with clinical signs of sepsis and pancytopenia. Investigations revealed parvovirus B19 (PVB19)-associated hemophagocytic lymphohistiocytosis (HLH). The patient recovered fully and quickly with symptomatic treatment. Current evidence suggests that PVB19-associated HLH has a favorable prognosis. Mild undiagnosed cases of HLH may be the cause of pancytopenia in PVB19 infections.
MeSH terms
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Child
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Glucosephosphate Dehydrogenase Deficiency* / genetics
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Glucosephosphate Dehydrogenase Deficiency* / pathology
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Glucosephosphate Dehydrogenase Deficiency* / therapy
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Humans
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Lymphohistiocytosis, Hemophagocytic* / diagnosis
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Lymphohistiocytosis, Hemophagocytic* / genetics
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Lymphohistiocytosis, Hemophagocytic* / pathology
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Lymphohistiocytosis, Hemophagocytic* / therapy
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Male
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Parvoviridae Infections* / diagnosis
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Parvoviridae Infections* / genetics
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Parvoviridae Infections* / pathology
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Parvoviridae Infections* / therapy
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Parvovirus B19, Human*
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Sepsis / diagnosis
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Sepsis / genetics
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Sepsis / pathology
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Sepsis / therapy