Parvovirus B19-associated Hemophagocytic Lymphohistiocytosis in a Patient With Glucose-6-phosphate Dehydrogenase Deficiency

J Pediatr Hematol Oncol. 2018 Nov;40(8):e550-e552. doi: 10.1097/MPH.0000000000001109.

Abstract

We report a case of a 12-year-old male with glucose-6-phosphate dehydrogenase deficiency presenting with clinical signs of sepsis and pancytopenia. Investigations revealed parvovirus B19 (PVB19)-associated hemophagocytic lymphohistiocytosis (HLH). The patient recovered fully and quickly with symptomatic treatment. Current evidence suggests that PVB19-associated HLH has a favorable prognosis. Mild undiagnosed cases of HLH may be the cause of pancytopenia in PVB19 infections.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Glucosephosphate Dehydrogenase Deficiency* / genetics
  • Glucosephosphate Dehydrogenase Deficiency* / pathology
  • Glucosephosphate Dehydrogenase Deficiency* / therapy
  • Humans
  • Lymphohistiocytosis, Hemophagocytic* / diagnosis
  • Lymphohistiocytosis, Hemophagocytic* / genetics
  • Lymphohistiocytosis, Hemophagocytic* / pathology
  • Lymphohistiocytosis, Hemophagocytic* / therapy
  • Male
  • Parvoviridae Infections* / diagnosis
  • Parvoviridae Infections* / genetics
  • Parvoviridae Infections* / pathology
  • Parvoviridae Infections* / therapy
  • Parvovirus B19, Human*
  • Sepsis / diagnosis
  • Sepsis / genetics
  • Sepsis / pathology
  • Sepsis / therapy