MAGE-A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer

Thorac Cancer. 2018 Apr;9(4):431-438. doi: 10.1111/1759-7714.12571. Epub 2018 Feb 12.

Abstract

Background: MAGE-A genes belong to the cancer/testis antigens family. The prognostic significance of MAGE-A expression in the peripheral blood of patients with lung cancer is unknown. Therefore, this study evaluated the expression and possible prognostic significance of MAGE-A in the peripheral blood of patients with lung cancer.

Methods: In this study, we detected MAGE-A gene expression in the peripheral blood of 150 patients with lung cancer and 30 healthy donors using multiplex semi-nested PCR and analyzed their correlation with clinicopathological risk factors.

Results: MAGE-A expression was associated with factors indicating poor prognosis. The expression of MAGE-A and each individual MAGE-A gene were also associated with low overall survival in patients with lung cancer.

Conclusion: The expression of MAGE-A genes in peripheral blood may act as a poor prognostic marker in patients with lung cancer.

Keywords: Biological marker; MAGE; lung cancer; metastasis; prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antigens, Neoplasm / blood
  • Biomarkers, Tumor / blood*
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lung Neoplasms / blood*
  • Lung Neoplasms / pathology
  • Male
  • Melanoma-Specific Antigens / blood
  • Melanoma-Specific Antigens / classification
  • Melanoma-Specific Antigens / genetics*
  • Middle Aged
  • Neoplasm Proteins / blood
  • Prognosis*

Substances

  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • MAGEA1 protein, human
  • MAGEA3 protein, human
  • MAGEA4 protein, human
  • MAGEA6 protein, human
  • MageA2 protein, human
  • Melanoma-Specific Antigens
  • Neoplasm Proteins