Objective: To analyze the etiology and drug sensitivity of lacrimal canaliculitis. Methods: Retrospective study of case series. The general information, culture results and drug sensitivity results of 52 patients (including 10 males and 42 females with an average age of 60.3 years) clinically diagnosed with lacrimal canaliculitis during 2011 and 2016 at Beijing Tongren Hospital of Capital Medical University have been analyzed. The enumeration data have been tested with Chi-square method. Results: The positive rate of bacterial culture was 78.8%, and the fungal culture tests of all cases showed negative results. Sixty strains of bacteria were isolated from 41 patients whose bacterial culture tests showed positive results, Gram-positive bacteria have been confirmed as the main among the isolated bacteria with Streptococcus (18.3%), Propionibacterium (18.3%), and Streptococcus (15.0%) identified as the three common genera. Thirteen cases (25.0%, all the 13 patients were female) involved with mixed infection, 13.3% (8/60) of the isolated strains were multi-drug resistant bacteria. The drug sensitive rate of the bacteria to fluoroquinolones antibiotics(79.3%, 230/290) was higher than that to cephalosporins(62.1%, 36/58) and aminoglycoside antibiotics(56.3%, 98/174), and such differences are of statistical significance (χ(2)=7.977, 27.738, P<0.05). Except for the fact that gram-positive bacteria are mostly sensitive to vancomycin, the sensitive rate of the bacteria to gatifloxacin was the highest and that to tobramycin was the lowest. Conclusion: Lacrimal canaliculitis tend to affect women and elderly patients. Staphylococcus, Propionibacterium, and Streptococcus are the three most common genera. Gatifloxacin may be the preferred antibiotic. Antibiotics combination therapy should be applied for multi-drug resistant bacteria. (Chin J Ophthalmol, 2018, 54: 111-114).
目的： 探讨泪小管炎的病原学及药物敏感性特征。 方法： 回顾性病例系列研究。选择2011至2016年于首都医科大学北京同仁眼科中心确诊为泪小管炎且未合并泪囊炎的患者52例，其中男性10例，女性42例。平均年龄60.3岁。分析患者的一般资料、细菌培养结果、药物敏感性试验结果。对计数资料进行卡方检验。 结果： 细菌培养阳性率为78.8%（41/52），真菌培养均为阴性。41例细菌培养阳性的患者，共分离出细菌60株，以革兰阳性菌为主，其中葡萄球菌属11株（18.3%）、丙酸杆菌属11株（18.3%）、链球菌属9株（15.0%）为常见菌属。13例患者（25.0%）为混合感染，均为女性；13.3%（8/60）的菌株为多重耐药菌。细菌对氟喹诺酮类抗生素敏感率（79.3%，230/290）高于头孢菌素类（62.1%，36/58）和氨基糖苷类（56.3%，98/174）抗生素，差异具有统计学意义（χ(2)=7.977，27.738；P<0.05）。除万古霉素以外，加替沙星对阳性菌的敏感性最高，妥布霉素为最低。 结论： 泪小管炎好发于女性、老年患者，葡萄球菌属、丙酸杆菌属、链球菌属为最常见的菌属，加替沙星可以作为首选抗生素，对于多重耐药菌应注意抗生素联合使用。（中华眼科杂志，2018，54：111-114）.
Keywords: Bacteria, anaerobic; Canaliculitis; Gram-positive bacteria; Microbial sensitivity tests.