Tetraspanin blockage reduces exosome-mediated HIV-1 entry

Arch Virol. 2018 Jun;163(6):1683-1689. doi: 10.1007/s00705-018-3737-6. Epub 2018 Feb 10.

Abstract

HIV-1 is one of the most studied retroviruses. The role of exosomes in HIV-1 entry and pathogenesis are beginning to be appreciated. Exosomes can incorporate host proteins that are also contained in viruses (e.g., tetraspanins).

MeSH terms

  • Antibodies, Neutralizing / pharmacology
  • CD4-Positive T-Lymphocytes / drug effects
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / virology
  • Cell Line
  • Culture Media, Conditioned / chemistry
  • Exosomes / chemistry*
  • Gene Expression
  • HEK293 Cells
  • HIV-1 / drug effects*
  • HIV-1 / physiology
  • Humans
  • Milk, Human / chemistry
  • Monocytes / drug effects
  • Monocytes / immunology
  • Monocytes / virology
  • Tetraspanin 28 / antagonists & inhibitors*
  • Tetraspanin 28 / genetics
  • Tetraspanin 28 / immunology
  • Tetraspanin 29 / antagonists & inhibitors*
  • Tetraspanin 29 / genetics
  • Tetraspanin 29 / immunology
  • Virus Internalization / drug effects*

Substances

  • Antibodies, Neutralizing
  • CD81 protein, human
  • CD9 protein, human
  • Culture Media, Conditioned
  • Tetraspanin 28
  • Tetraspanin 29