Hepatobiliary phase liver MR imaging findings after Oxaliplatin-based chemotherapy in cancer patients

Abdom Radiol (NY). 2018 Sep;43(9):2321-2328. doi: 10.1007/s00261-018-1482-7.

Abstract

Objective: To describe Gd-EOB-DTPA-enhanced liver MR imaging findings in colon and rectal cancer patients who received Oxaliplatin.

Conclusion: Spectrum of hepatobiliary phase imaging findings include diffuse heterogeneous dysfunction, macronodular and micronodular FNH-like lesions, and coexistence of periportal increased liver function with FNH-like lesions. Differentiation of these benign lesions from metastasis is crucial to avoid biopsy in patients with colorectal cancers and may allow better understanding of sinusoidal obstruction syndrome pathophysiology and regenerative response of liver.

Keywords: Colorectal cancer; FNH-like lesion; Gd-EOB-DTPA; Hepatobiliary phase; Liver MRI; Oxaliplatin; Sinusoidal obstruction syndrome.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols
  • Chemical and Drug Induced Liver Injury / diagnostic imaging*
  • Colorectal Neoplasms / drug therapy*
  • Contrast Media
  • Female
  • Fluorouracil
  • Gadolinium DTPA
  • Humans
  • Leucovorin
  • Liver Function Tests
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Organoplatinum Compounds
  • Oxaliplatin / adverse effects*

Substances

  • Antineoplastic Agents
  • Contrast Media
  • Organoplatinum Compounds
  • gadolinium ethoxybenzyl DTPA
  • Oxaliplatin
  • Gadolinium DTPA
  • Leucovorin
  • Fluorouracil

Supplementary concepts

  • Folfox protocol