Reduced frontal activity during a verbal fluency test in fibromyalgia: A near-infrared spectroscopy study

Po-Han Chou; Kuo-Tung Tang; Yi-Hsing Chen; Chia-Wei Sun; Chih-Mao Huang; Der-Yuan Chen

doi:10.1016/j.jocn.2018.01.030

Reduced frontal activity during a verbal fluency test in fibromyalgia: A near-infrared spectroscopy study

J Clin Neurosci. 2018 Apr:50:35-40. doi: 10.1016/j.jocn.2018.01.030. Epub 2018 Feb 14.

Authors

Po-Han Chou¹, Kuo-Tung Tang², Yi-Hsing Chen³, Chia-Wei Sun⁴, Chih-Mao Huang⁵, Der-Yuan Chen⁶

Affiliations

¹ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Department of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Biomedical Optical Imaging Lab, Department of Photonics, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, Taiwan; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
² Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan; Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan.
³ Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address: ysanne@vghtc.gov.tw.
⁴ Biomedical Optical Imaging Lab, Department of Photonics, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, Taiwan.
⁵ Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
⁶ School of Medicine, National Yang-Ming University, Taipei, Taiwan; Rheumatology and Immunology Center, China Medical University Hospital, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan.

PMID: 29426783
DOI: 10.1016/j.jocn.2018.01.030

Abstract

Fibromyalgia (FM) is a complex disorder characterized by widespread chronic pain and associated sleep problems and cognitive dysfunction. However, only few studies focusing on cognitive dysfunction in FM are available so far. In the present study, we aimed to use near infrared spectroscopy (NIRS) to evaluate the brain function in FM patients subjected to a verbal fluency test (VFT). A total of 11 primary FM patients and 13 healthy individuals (HC) underwent NIRS while performing a VFT. The Fibromyalgia Impact Questionnaire (FIQ) was used to evaluate the symptom severity of FM and Beck Depression Inventory II (BDI) was used to evaluate the severities depression symptoms in study participants. Five regions of interests (ROIs) were defined: the frontal-, bilateral inferior frontal gyrus (IFG), and temporal regions. Brain activities of ROIs between the two groups were compared. In addition, we investigated the relationship between clinical symptoms and brain cortical activity in FM patients. Our results showed that there were no significant differences between HC and FM patients in age, sex, and BDI scores. We found significantly reduced brain activity over the frontal regions during a VFT in FM patients (p = .026). In addition, we found decreased frontal activity was associated with BDI scores (rho = -0.755, p = .007). Furthermore, there were no significant correlations between frontal activity and FIQ subscales. In conclusion, our study demonstrated a reduced frontal cortical activity during VFT in FM patients, and that NIRS could be a potential tool for evaluating brain function in FM patients in clinical settings.

Keywords: Brain dysfunction; Cognition; Fibromyalgia; NIRS; Near infrared spectroscopy.

MeSH terms

Adult
Depression / physiopathology*
Depression / psychology
Female
Fibromyalgia / physiopathology*
Fibromyalgia / psychology*
Frontal Lobe / physiopathology*
Humans
Male
Middle Aged
Spectroscopy, Near-Infrared / methods
Verbal Behavior / physiology*