Effectiveness of a bioactive food compound in anthropometric measures of individuals with HIV/AIDS: A nonrandomized trial

PLoS One. 2018 Feb 9;13(2):e0191259. doi: 10.1371/journal.pone.0191259. eCollection 2018.

Abstract

Background: Highly Active Antiretroviral therapy (HAART) promotes anthropometric changes in lipid metabolism and glucose in patients with Human Immunodeficiency Virus (HIV). Functional foods play an important role on metabolism. Bioactive Food Compound (BFC) has shown effective results in changes arising from decompensated lipid metabolism due to the effects of HAART on HIV patients. From this perspective, the objective of this study is to evaluate anthropometric indicators and the body composition of patients undergoing HAART before and after consumption of BFC.

Methods: This is a prospective intervention with 180 individuals with HIV undergoing HAART. They formed two groups and were monitored for 3 months: the first group consisted of individuals who consumed BFC (n = 121) at the recommended daily intake of 40 g. The second group consisted of individuals who did not consume BFC (n = 59). We determined body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), conicity index (CI) and antiretroviral regimen used by the patients.

Results: The BMI among adults (p<0.001), the WC (p<0.001 and p<0.014 for men and women, respectively) and the CI (p = 0.001 and p<0.001 for men and women, respectively) increased at the end of the study in the group of individuals who did not consume BFC and remained stable in the BFC group. There were no changes in WHR in any of the groups evaluated. Regarding the antiretroviral regimens used, we observed that there was no difference between regimens as for BMI, WC, WHR and CI.

Conclusions: The BFC consumed by HIV patients undergoing HAART allowed the maintenance of anthropometric measures without increasing the mean values of conicity index, suggesting that the consumption of this bioactive compound protects the individual against the development of metabolic syndrome (MeS) in patients infected with HIV undergoing antiretroviral therapy.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anthropometry
  • Antiretroviral Therapy, Highly Active / adverse effects
  • Body Composition
  • Body Mass Index
  • Female
  • Functional Food*
  • Glucose / metabolism
  • HIV Infections / diet therapy*
  • HIV Infections / drug therapy
  • HIV Infections / pathology*
  • Humans
  • Lipid Metabolism
  • Male
  • Metabolic Syndrome / etiology
  • Metabolic Syndrome / metabolism
  • Metabolic Syndrome / prevention & control
  • Middle Aged
  • Obesity, Abdominal / etiology
  • Obesity, Abdominal / pathology
  • Obesity, Abdominal / prevention & control
  • Prospective Studies
  • Waist Circumference
  • Waist-Hip Ratio
  • Young Adult

Substances

  • Glucose

Grants and funding

The Foundation for Support to the Development of Education, Science and Technology of the State of Mato Grosso do Sul (FUNDECT) is a research support institution in the state of Mato Grosso do Sul / Brazil, and through the call FUNDECT/ MS/ CNPq/SES N ° 07/2009 - was approved the research project titled: “Bioative compound: nutritional therapeutics in the lipidic and glycemic alterations for HIV infection in individuals using combined antiretroviral therapy,” coordinated by Rosângela dos Santos Ferreira (RSF). The URLs of the Foundation is: http://fundect.ledes.net/. We would like to inform that the database of this project has made it possible to prepare some manuscripts, including the title: The effectiveness of a bioactive food compound in anthropometric measures of individuals with HIV/ AIDS submitted to this Journal Plos One, which will be appreciated by the body Editorial of this journal, and subsequent evaluation by its reviewers, culminating in necessary adjustments, which we will undertake to do, for publication of the manuscript. We reaffirm that the phases of idealization, design, analysis, discussion, construction and conception of this manuscript were carried out exclusively by the informed authors. However, we inform you that there was no FUNDECT participation at any stage of preparation of the manuscript. The research group would like to thank the contribution by the Foundation for Support to the Development of Education, Science and Technology of the State of Mato Grosso do Sul (FUNDECT) - 0025/10. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.