The prognosis role of AJCC/UICC 8th edition staging system in gastric cancer, a retrospective analysis

Jiu-Yang Liu; Chun-Wei Peng; Xiao-Jun Yang; Chao-Qun Huang; Yan Li

The prognosis role of AJCC/UICC 8^th edition staging system in gastric cancer, a retrospective analysis

Am J Transl Res. 2018 Jan 15;10(1):292-303. eCollection 2018.

Authors

Jiu-Yang Liu¹, Chun-Wei Peng¹, Xiao-Jun Yang¹, Chao-Qun Huang¹, Yan Li^{1

2}

Affiliations

¹ Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study CenterNo. 169 Donghu Road, Wuchang District, Wuhan 430071, P. R. China.
² Department of Peritoneal Cancer Surgery, Cancer Center of Beijing Shijitan Hospital Affiliated to The Capital Medical UniversityNo. 10 Tieyi Road, Yangfangdian, Beijing 100038, P. R. China.

PMID: 29423014
PMCID: PMC5801367

Abstract

Objective: The present study was designed to investigate whether AJCC/UICC 8^th edition staging system precisely differentiated patients with different prognosis of gastric cancer (GC).

Methods: There were 540 GC cases included in this study. Stratification was done according to the 7^th and 8^th AJCC/UICC tumor-node-metastasis (TNM) staging systems. Detailed comparison was conducted between two editions in terms of the sub-classification of pN3 stage, redefinitions of stage III, homogeneity, discrimination power, predictive accuracy, and complexity.

Results: Compared to the 7^th edition, the 8^th TNM staging system performed better by incorporating pN3a and pN3b into the final stage of GC (P<0.001), had better stage grouping homogeneity (P<0.001), prognostic value (area under the curve, AUC-value was 0.809), and comparable discrimination power.

Conclusions: AJCC 8^th TNM staging system showed improved efficiency in GC prognosis.

Keywords: AJCC; Gastric cancer; prognosis; staging system.