Primary diffuse leptomeningeal melanomatosis: Description and recommendations

Yamaan S Saadeh; Todd C Hollon; Amanda Fisher-Hubbard; Luis E Savastano; Paul E McKeever; Daniel A Orringer

doi:10.1016/j.jocn.2018.01.052

Primary diffuse leptomeningeal melanomatosis: Description and recommendations

J Clin Neurosci. 2018 Apr:50:139-143. doi: 10.1016/j.jocn.2018.01.052.

Authors

Yamaan S Saadeh¹, Todd C Hollon¹, Amanda Fisher-Hubbard², Luis E Savastano¹, Paul E McKeever², Daniel A Orringer³

Affiliations

¹ Departments of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
² Departments of Pathology, University of Michigan, Ann Arbor, MI, USA.
³ Departments of Neurosurgery, University of Michigan, Ann Arbor, MI, USA. Electronic address: dorringe@med.umich.edu.

PMID: 29422361
DOI: 10.1016/j.jocn.2018.01.052

Abstract

Primary melanocytic disease of the central nervous system is a rarely encountered condition currently without consensus on treatment and lacking major guidelines for management. Understanding the nature of the disease and differentiating primary melanocytic disease from the much more commonly encountered secondary (metastatic) melanoma is important in identifying the condition and pursuing appropriate treatment.

Keywords: Central nervous system; Hydrocephalus; Leptomeningeal melanomatosis; Melanocytic disease.

Publication types

Case Reports

MeSH terms

Aged
Carcinoma, Papillary / pathology
Female
Humans
Melanocytes / pathology*
Melanoma / pathology*
Meningeal Carcinomatosis / pathology*
Neoplasms, Second Primary / pathology
Urinary Bladder Neoplasms / pathology