Vitamin D and Subjective Memory Complaint in Community-Dwelling Older Adults

Cedric Annweiler; Lise Doineau; Lucie Gerigne; Anais Provendier; Spyridon N Karras; Olivier Beauchet; Bruno Fantino; Guillaume T Duval

doi:10.2174/1567205015666180201153735

Vitamin D and Subjective Memory Complaint in Community-Dwelling Older Adults

Curr Alzheimer Res. 2018;15(7):664-670. doi: 10.2174/1567205015666180201153735.

Authors

Cedric Annweiler^{1

2

3}, Lise Doineau³, Lucie Gerigne³, Anais Provendier³, Spyridon N Karras⁴, Olivier Beauchet¹, Bruno Fantino¹, Guillaume T Duval¹

Affiliations

¹ Department of Geriatric Medicine, University Memory Clinic, UPRES EA 4638, Angers University Hospital, Angers, France.
² Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, Ontario, Canada.
³ School of Medicine, University of Angers, UNAM, Angers, France.
⁴ Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

PMID: 29422004
DOI: 10.2174/1567205015666180201153735

Abstract

Background: Older adults with hypovitaminosis D report more often subjective cognitive complaints, especially with regards to memory. This raises prospects that vitamin D may improve older adults' subjective experience of memory disorders.

Objective: To determine among older community-dwellers whether higher serum 25- hydroxyvitamin D (25OHD) concentrations were associated with fewer memory complaints, while considering different subtypes of memory complaints.

Method: One hundred eighty Caucasian community-dwellers with memory complaint and no dementia (mean±standard deviation, 71.1±3.4years; 33.3%female) from the French 'EVATEM study' were included in this analysis. Subjective memory complaints regarding memory lapses, problems learning new information, problems finding words, problems calculating and problems concentrating were assessed using a standardized questionnaire. Participants were categorized according to the highest tertile of serum 25OHD (i.e., ≥68nmol/L). Age, gender, body mass index, morbidities burden, use of vitamin D supplements, cognitive performance, mood, serum concentrations of calcium, parathyroid hormone and vitamin B12, creatinine clearance, and season of evaluation were used as potential confounders.

Results: Compared to participants with 25OHD<68nmol/L (n=121), those with 25OHD≥68nmol/L had less often problems learning new information (P=0.027). There were no between-group differences for the other memory complaints. The highest 25OHD tertile was cross-sectionally associated with fewer problems learning new information (odds ratio (OR)=0.48, P=0.029), even after adjustment for potential confounders (OR=0.32, P=0.039).

Conclusion: Higher vitamin D status was associated with reduced problems memorizing new information in older community-dwellers. This novel finding provides a scientific base for vitamin D replacement trials attempting to improve older patients' subjective experience of cognitive decline.

Keywords: Cognition; dementia; learning; neuroendocrinology; older adults; subjective memory complaint; vitamin D..

MeSH terms

Aged
Biomarkers / blood
Cross-Sectional Studies
Diagnostic Self Evaluation
Female
Humans
Independent Living
Male
Memory Disorders / blood*
Perception
Vitamin D / analogs & derivatives*
Vitamin D / blood
Vitamin D Deficiency / blood
Vitamin D Deficiency / psychology

Substances

Biomarkers
Vitamin D
25-hydroxyvitamin D