Β-defensins - Underestimated peptides in influenza combat

Abstract

Defensins are a family of host defense peptides present in vertebrates, invertebrates and plants. They display broad antimicrobial activity and immunomodulatory functions. Herein, the natural anti-influenzal role of β-defensins, as well as their potential usage as anti-influenza vaccine adjuvants and therapeutic agents, is reviewed. This article summarizes previously published information on β-defensin modes of action, expression changes after influenza infection and vaccination, biotechnological usage and possible boosting of their production by dietary supplementation.

Keywords: Antimicrobial peptides; Antivirals; Defensin; Dietary stimulation; Immunomodulation; Influenza.