Reprograming immunity to food allergens

Ashley L St John; W X Gladys Ang; Abhay P S Rathore; Soman N Abraham

doi:10.1016/j.jaci.2018.01.020

Reprograming immunity to food allergens

J Allergy Clin Immunol. 2018 May;141(5):1936-1939.e2. doi: 10.1016/j.jaci.2018.01.020. Epub 2018 Feb 5.

Authors

Ashley L St John¹, W X Gladys Ang², Abhay P S Rathore³, Soman N Abraham⁴

Affiliations

¹ Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore; Department of Microbiology and Immunology, National University of Singapore, Singapore; Department of Pathology, Duke University Medical Center, Durham, NC.
² Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC.
³ Department of Pathology, Duke University Medical Center, Durham, NC.
⁴ Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore; Department of Pathology, Duke University Medical Center, Durham, NC; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC; Department of Immunology, Duke University Medical Center, Durham, NC. Electronic address: soman.abraham@duke.edu.

Abstract

A novel immune-modulatory therapy utilizing targeted delivery of cytokines to draining lymph nodes effectively reprograms Th2 allergic responses towards a Th1 and tolerogenic profile, resulting in protection from peanut antigen-induced anaphylaxis.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Allergens / immunology*
Animals
Female
Food / adverse effects*
Food Hypersensitivity / immunology*
Humans
Immunity / immunology*
Immunotherapy / methods
Mice
Mice, Inbred C57BL
Th1 Cells / immunology
Th2 Cells / immunology

Substances

Allergens

Abstract

Publication types

MeSH terms

Substances

Grants and funding