Macronutrient Composition and Food Form Affect Glucose and Insulin Responses in Humans

Nutrients. 2018 Feb 8;10(2):188. doi: 10.3390/nu10020188.

Abstract

Glycaemic index (GI) is used as an indicator to guide consumers in making healthier food choices. We compared the GI, insulin index (II), and the area under the curve for blood glucose and insulin as glucose (GR) and insulin responses (IR) of a newly developed liquid nutritional formula with one commercially available liquid product with different types of carbohydrates. We then evaluated the glucose and insulin responses of two test foods with comparable energy density and protein percentage but presented in different food forms (liquid vs. solid). Fourteen healthy women participated in the study. GI, II, GR, and IR were assessed after (independent) consumption of two liquid products and a solid breakfast meal. The two liquid foods showed comparable GI, whilst the liquid form appeared to produce lower median GI (25 vs. 54), and II (52 vs. 98) values compared to the solid breakfast (p < 0.02). The median GR and IR for solid breakfast were respectively 44% and 45% higher compared to the liquid product (p < 0.02). Liquid formulas with different carbohydrate qualities produced comparable glucose responses, while foods with comparable energy density and protein percentage but different food form elicited differential effects on GI, II, GR, and IR. Nutrient quality and food form need to be taken into consideration when developing low GI products to manage glycaemic responses.

Keywords: carbohydrate quality; glycaemic and insulin responses; glycaemic index; insulinemic index; nutritional formula; protein quality.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Area Under Curve
  • Beverages* / adverse effects
  • Biomarkers / blood
  • Blood Glucose / analysis
  • Breakfast
  • Cross-Over Studies
  • Diet / adverse effects
  • Dietary Carbohydrates / adverse effects
  • Dietary Carbohydrates / metabolism
  • Dietary Carbohydrates / therapeutic use*
  • Digestion
  • Female
  • Food, Formulated* / adverse effects
  • Glycemic Index*
  • Humans
  • Hyperglycemia / blood
  • Hyperglycemia / etiology
  • Hyperglycemia / metabolism
  • Hyperglycemia / prevention & control*
  • Hyperinsulinism / blood
  • Hyperinsulinism / etiology
  • Hyperinsulinism / metabolism
  • Hyperinsulinism / prevention & control*
  • Insulin / blood
  • Insulin Resistance*
  • Nutritive Value
  • Postprandial Period
  • Reproducibility of Results
  • Young Adult

Substances

  • Biomarkers
  • Blood Glucose
  • Dietary Carbohydrates
  • Insulin